A recent study reveals that individuals who come off popular slimming jabs like semaglutide or tirzepatide may regain lost weight much more quickly than those who end conventional diet and exercise programs.
Findings released in a leading medical journal demonstrates that while obese individuals can lose about a fifth of their total mass while on the medication, the weight comes back at an estimated rate of nearly a kilo each month after stopping.
"Individuals purchasing these treatments need to be cognizant of the risk of fast rebound weight gain when the medication ends," warns lead investigator Dr. Susan Jebb.
That rate of regain suggests a reversion to starting mass in about a year and a half.
Weighing Therapies
The analysis, which reviewed dozens of studies involving over 9,000 of patients, compared the outcomes of GLP-1 agonists with conventional dieting.
Researchers point out that people who lose weight through diet and exercise usually experience a less rapid creep back—around 100 grams monthly—after stopping.
Explaining the Quick Regain
Nutrition scientists believe the way of the injections is key to understanding the amplified rebound.
GLP-1 drugs imitate a natural hormone called glucagon-like peptide-1, which moderates hunger.
"Artificially providing the hormone concentrations several times higher than normal might result in the body to produce less of its own natural hormone, and could diminish sensitivity to its effects," said Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this GLP-1 'fix' means appetite is unsuppressed, making binge eating far more likely."
An Ongoing Condition?
The NHS recommend the injections for people with weight-linked medical conditions, accompanied by prescribed diet and exercise modifications.
Professionals contend that, given the likelihood of weight regain, the treatment might need to be long-term.
This view is supported by pharmaceutical companies, who note that the findings "underscore the chronic character of obesity," akin to managing conditions like high blood pressure.
Patient Accounts
Individuals who have come off the medication report a powerful resurgence of cravings.
"It felt as if something that goes on and you're instantly ravenous," said a patient.
The struggle is exacerbated if users have not developed lasting dietary or behavioural modifications during therapy.
Widespread Use
Figures indicate that a significant number of adults in the UK have used weight-loss jabs in the past year, with desire remaining high.
- Adoption is greater among women than men.
- The 40s and 50s age group shows the greatest level of interest.
- Many access the medications through private healthcare rather than the NHS.
Finally, experts stress that while these medications are effective agents for shedding pounds, they are not a permanent solution and long-term success relies on integrated behavioural support.
